Cytotoxic Germacranolide Sesquiterpene from Inula cappa

    • XIE Hong-Gang
    • Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College
    • CHEN Hong
    • Department of Pharmacology, Medical College of Chinese People's Armed Police Forces
    • CAO Bo
    • Department of Pharmacology, Medical College of Chinese People's Armed Police Forces
    • ZHANG Hong-Wu
    • Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College
    • ZOU Zhong-Mei
    • Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College

Abstract

A new germacranolide, inulacappolide (1), was isolated from the EtOH extract of the whole plant of Inula cappa along with 16 known compounds. The structure of inulacappolide was a rare 1(10)-saturated type of germacran-6,12-olide, identified as 2α-acetoxy-3β-hydroxy-9β-angeloyloxygermacra-4-en-6α,12-olide by spectral analysis (IR, HR-ESI/MS, ^1H-NMR, ^<13>C-NMR, HMQC, HMBC, NOESY). In vitro, it showed antiproliferative effects against human cervical cancer HeLa, human leukemia K562 and human nasopharyngeal carcinoma KB cell lines with IC_<50> values of 1.2μM, 3.8μM and 5.3μM, respectively.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 55(8), 1258-1260, 2007-08-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  17

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Cited by:  2

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Codes

  • NII Article ID (NAID) :
    110006366550
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00092363
  • NDL Article ID :
    8825006
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.55.1258
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE