A New Flavanone Glycoside from the Dried Immature Fruits of Poncirus trifoliata

    • HAN Ah-Reum
    • College of Pharmacy and Center for Cell Signaling & Drug Discovery Research, Ewha Womans University
    • LEE Jun
    • College of Pharmacy and Center for Cell Signaling & Drug Discovery Research, Ewha Womans University
    • NAM Joo-Won
    • College of Pharmacy and Center for Cell Signaling & Drug Discovery Research, Ewha Womans University
    • LEE Ik-Soo
    • College of Pharmacy and Research Institute of Drug Development, Chonnam National University
    • SHIM Chang-Koo
    • Department of Pharmaceutics, College of Pharmacy, Seoul National University
    • SEO Eun-Kyoung
    • College of Pharmacy and Center for Cell Signaling & Drug Discovery Research, Ewha Womans University

Abstract

A new flavanone glycoside, (2R)-5-hydroxy-4'-methoxyflavanone-7-O-{β-glucopyranosyl-(1→2)-β-glucopyranoside} (1), was isolated from the EtOAc extract of dried immature fruit of Poncirus trifoliata, together with three known compounds, (2S)-poncirin (2), (2S)-naringin (3), and (2S)-poncirenin (4). The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. Among the isolates, compound 2 exhibited considerable inhibitory activity against lipopolysaccharide (LPS)-induced prostaglandin E_2 (PGE_2) and interleukin-6 (IL-6) production, and mRNA expression in RAW 264.7 murine macrophage cells.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 55(8), 1270-1273, 2007-08-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  30

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Cited by:  1

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Codes

  • NII Article ID (NAID) :
    110006366554
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00092363
  • NDL Article ID :
    8825135
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.55.1270
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE