肥満小児に対する食事療法と運動療法を主体とした減量が血中グレリン濃度に及ぼす影響

DOI 機関リポジトリ HANDLE Web Site Web Site 参考文献54件

書誌事項

タイトル別名
  • IMPACT OF A DIET AND EXERCISE PROGRAM FOR OBESE CHILDREN ON SERUM GHRELIN LEVELS
  • ヒマン ショウニ ニ タイスル ショクジ リョウホウ ト ウンドウ リョウホウ オ シュタイ ト シタ ゲンリョウ ガ ケッチュウ グレリン ノウド ニ オヨボス エイキョウ

この論文をさがす

抄録

Ghrelin, an endogenous ligand for the growth hormone (GH) secretagogue receptor, has been reported to induce a GH-releasing, orexigenic effect on weight gain, and adipogenic actions. It is, therefore, thought that ghrelin links the regulatory systems for growth and energy balance.<br>We examined 25 obese children undergoing a 3-month inpatient weight reduction program for obese children based on a combination of diet and exercise therapy and evaluated the change in the serum ghrelin levels.<br>The subjects consisted of 25 children with moderate to severe simple obesity [17 boys, 8 girls ; mean age 9.9±1.3 years, percent overweight (% overweight) 52.1±13.6%]. Height, weight, percent body fat (% BF), fat mass, fat-free mass (FFM), and serum ghrelin were measured before and after weight reduction.<br>After therapy, body weight, % BF and fat mass had all significantly decreased (p<0.001), while height and FFM had both significantly increased (p<0.001 ; p<0.05, respectively). There were no correlations between pre-therapy serum ghrelin and any of the following: initial height, weight, % overweight, % BF, fat mass, or FFM. However, after therapy, serum ghrelin levels were negatively correlated with body weight (rs=-0.544, p<0.01). Serum ghrelin levels increased significantly from pre- to post-therapy (113.9±30.7 to 129.6±42.9 fmol/ml, p<0.05). The rate of changes in ghrelin levels was negatively correlated with the rate of change in the % overweight (rs=-0.412, p<0.05).<br>These findings suggest that long-term weight reduction based on a combination of diet and exercise therapy lessens the severity of obesity and increases serum ghrelin levels in obese children.

収録刊行物

  • 体力科学

    体力科学 56 (4), 419-428, 2007

    一般社団法人日本体力医学会

参考文献 (54)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ