Randomized trial of statin administration for myocardial injury: is intensive lipid-lowering more beneficial than moderate lipid-lowering before percutaneous coronary intervention?

• Kinoshita Masayoshi

  Division of Cardiology, Department of Internal Medicine, Keio University School of Medicine Division of Cardiology, The Shizuoka Municipal Shimizu Hospital Division of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine

• Matsumura Shin-ichirou

  Division of Cardiology, Department of Internal Medicine, Keio University School of Medicine Division of Cardiology, The Shizuoka Municipal Shimizu Hospital

• Sueyoshi Kouichirou

  Division of Cardiology, Department of Internal Medicine, Keio University School of Medicine Division of Cardiology, The Shizuoka Municipal Shimizu Hospital

• Ogawa Satoshi

  Division of Cardiology, Department of Internal Medicine, Keio University School of Medicine

• Fukuda Keiichi

  Division of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine

書誌事項

タイトル別名

• Randomized Trial of Statin Administration for Myocardial Injury
• Is Intensive Lipid-Lowering More Beneficial Than Moderate Lipid-Lowering Before Percutaneous Coronary Intervention?

抄録

Background Minor myocardial damage after percutaneous coronary intervention (PCI) is associated with cardiac risks, which statins seem to reduce. The aim of this study was to examine whether intensive lipid-lowering therapy is more effective in decreasing the risk of cardiac injury after PCI than moderate lipid-lowering therapy. Methods and Results Subjects comprised 42 patients with stable angina without previous statin treatment, randomly assigned to either an intensive lipid-lowering group (Group A: target low-density lipoprotein-cholesterol (LDL-C) <70 mg/dl) or a moderate lipid-lowering group (Group B: target LDL-C <100 mg/dl) 2 weeks before PCI. All patients took statins to reach target LDL-C levels. Incidence of periprocedural myocardial injury was assessed by analyzing levels of creatine kinase myocardial isozyme (CK-MB) and cardiac troponin T (TnT) before and 6, 12 and 24 h after PCI. Minor myocardial damage was defined as TnT elevation to >0.01 ng/ml. Frequency of minor myocardial damage was 14.2% in Group A and 47.6% in Group B (p=0.043). CK-MB was above the upper limit of normal (ULN) in 19% of Group A and 33.3% of Group B (p=0.44), and CK-MB was >3× ULN in 9.5% of Group A and 19% of Group B (p=0.66). Conclusions Intensive lipid-lowering therapy before PCI reduces minor myocardial damage during PCI with stenting compared with moderate lipid-lowering therapy. (Circ J 2007; 71: 1225 - 1228)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 71 (8), 1225-1228, 2007

  一般社団法人 日本循環器学会

キーワード

• Angioplasty
• Cholesterol
• Stents

詳細情報

• CRID: 1390282680081324416
• NII論文ID: 110006368846
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.71.1225
• ISSN: 13474820
• ISSN: 13469843
• Web Site: https://www.jstage.jst.go.jp/article/circj/71/8/71_8_1225/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008033330
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可