Effects of Phenyl Derivatives of Dihydropyrazines with Ability to Generate Radical Species on Escherichia coli

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Phenyl-substituted dihydropyrazines (Ph-DHPs) are derivatives of 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP). Upon the addition of Cu2+, Me-DHP inhibits the growth of Escherichia coli by generating hydroxyl and carbon-centered radicals that cause DNA strand breakage. Here, we investigated the toxic effect of Ph-DHPs in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains. Ph-DHPs caused cytotoxic and genotoxic damage, but, in a sodA sodB strain, the effects in the presence or absence of Cu2+ were different than those of Me-DHP. Our results suggest that the action of the generated superoxide anion in the interior side of the cell is remarkable.

収録刊行物

  • Biological & pharmaceutical bulletin

    Biological & pharmaceutical bulletin 30(9), 1663-1667, 2007-09-01

    公益社団法人日本薬学会

参考文献:  15件中 1-15件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    110006380246
  • NII書誌ID(NCID)
    AA10885497
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09186158
  • NDL 記事登録ID
    8877755
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-V41
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS  J-STAGE 
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