A Survey of Synthetic and Natural Phytotoxic Compounds and Phytoalexins as Potential Antimalarial Compounds
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- Bajsa Joanna
- National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, U.S.A.
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- Singh Kshipra
- National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, U.S.A.
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- Nanayakkara Dhammika
- National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, U.S.A.
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- Duke Stephen Oscar
- USDA, ARS, Natural Products Utilization Research Unit
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- Rimando Agnes Mamaril
- USDA, ARS, Natural Products Utilization Research Unit
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- Evidente Antonio
- Dipartimento di Scienze del Suolo, della Pianta, dell'Ambiente e delle Produzioni Animali, Università di Napoli Federico II
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- Tekwani Babu Lal
- National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, U.S.A.
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The apicomplexan parasites pathogens such as Plasmodium spp. possess an apicoplast, a plastid organelle similar to those of plants. The apicoplast has some essential plant-like metabolic pathways and processes, making these parasites susceptible to inhibitors of these functions. The main objective of this paper is to determine if phytotoxins with plastid target sites are more likely to be good antiplasmodial compounds than are those with other modes of action. The antiplasmodial activities of some compounds with established phytotoxic action were determined in vitro on a chloroquine (CQ) sensitive (D6, Sierra Leone) strain of Plasmodium falciparum. In this study, we provide in vitro activities of almost 50 such compounds, as well as a few phytoalexins against P. falciparum. Endothall, anisomycin, and cerulenin had sufficient antiplasmodial action to be considered as new lead antimalarial structures. Some derivatives of fusicoccin possessed markedly improved antiplasmodial action than the parent compound. Our results suggest that phytotoxins with plastid targets may not necessarily be better antiplasmodials than those that act at other molecular sites. The herbicides, phytotoxins and the phytoalexins reported here with significant antiplasmodial activity may be useful probes for identification of new antimalarial drug targets and may also be used as new lead structures for new antiplasmodial drug discovery.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 30 (9), 1740-1744, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679605063040
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- NII論文ID
- 110006380260
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 8877958
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可