Determination of Paracetamol and Orphenadrine Citrate in Pharmaceutical Tablets by Modeling of Spectrophotometric Data Using Partial Least-Squares and Artificial Neural Networks

• SRATTHAPHUT Lawan

  Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University

• RUANGWISES Nongluck

  Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University

抄録

  The estimation of paracetamol and orphenadrine citrate in a multicomponent pharmaceutical dosage form by spectrophotometric method has been reported. Because of highly interference in the spectra and the presence of non-linearity caused by the analyte concentrations which deviate from Beer and Lambert's law, partial least-squares (PLS) and artificial neural networks (ANN) techniques were used for the calibration. A validation set of spiked samples was employed for testing the accuracy and precision of the methods. Reasonably good recoveries were obtained with PLS for paracetamol and the use of an ANN allowed the estimation of orphenadrine citrate, a minor component which could not be adequately modeled by PLS. Three production batches of a commercial sample were analysed, and there was statistically no significant difference (P<0.05) between the results with the proposed method and those obtain with the official comparative method.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 127 (10), 1723-1729, 2007-10-01

  公益社団法人 日本薬学会

キーワード

• paracetamol
• orphenadrine citrate
• partial least-squares
• artificial neural networks
• spectrophotometry

詳細情報

• CRID: 1390001206127085312
• NII論文ID: 110006402957
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.127.1723
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 8964700
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8964700
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/127/10/127_10_1723/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008081342
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可