ウシ好中球の活性酸素生成および細胞内情報伝達におよぼす補体受容体(CR3)および免疫グロブリンIgG-Fcに対する受容体(FcγR)への共刺激

• NAGAHATA Hajime

  Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University

• HIGUCHI Hidetoshi

  Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University

• INANAMI Osamu

  Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University

• KUWABARA Mikinori

  Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University

書誌事項

タイトル別名

• Costimulatory Effects of Complement Receptor Type 3 and Fc Receptor for IgG (Fc.GAMMA.R) on Superoxide Production and Signal Transduction in Bovine Neutrophils
• Immunology: Costimulatory effects of complement receptor type 3 and Fc receptor for IgG (FcγR) on superoxide production and signal transduction in bovine neutrophils
• Immunology Costimulatory effects of complement receptor type 3 and Fc receptor for IgG FcgR on superoxide production and signal transduction in bovine neutrophils

抄録

The present study evaluated the costimulatory effects of complement receptor type 3 (CR3) and Fc receptor for IgG (FcγR) on superoxide production and intracellular signal transduction in bovine neutrophils. Stimulation with opsonized zymosan (OPZ) and heat-aggregated bovine IgG (Agg-IgG) resulted in much greater superoxide production and chemiluminescent (CL) responses in normal neutrophils compared with those stimulated with OPZ or Agg-IgG only. Superoxide production and CL response were closely associated with the stimulant-induced rise of the intracellular calcium ([Ca²⁺]_i) concentration, amount of tyrosine phosphorylated 100 kDa protein, and activation of p38 mitogen-activated protein kinase (p38 MAPK). No costimulatory effect was found for these receptors on superoxide production in CR3-deficient neutrophils. Costimulation of CR3 and FcγR on bovine neutrophils leads to enhancement of superoxide production and their signaling pathways and appears to be associated with enhancement of neutrophil functions.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 69 (10), 993-997, 2007

  公益社団法人 日本獣医学会

キーワード

• bovine neutrophils
• costimulation
• CR3
• FcγR
• signaling pathway

詳細情報

• CRID: 1390001206427717760
• NII論文ID: 110006418716
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.69.993
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 8985426
• Web Site: https://agriknowledge.affrc.go.jp/RN/2030760041
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8985426
• Web Site: http://www.jstage.jst.go.jp/article/jvms/69/10/69_10_993/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008043061
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可