THIRTEEN-WEEK REPEATED DOSE ORAL TOXICITY STUDY OF COENZYME Q10 IN RATS

• HONDA Kumiko

  Department of Toxicology, Panapharm Laboratories Co., Ltd.

• TOMINAGA Sayumi

  Department of Toxicology, Panapharm Laboratories Co., Ltd.

• OSHIKATA Takafumi

  Department of Toxicology, Panapharm Laboratories Co., Ltd.

• KAMIYA Kouichi

  Department of Toxicology, Panapharm Laboratories Co., Ltd.

• HAMAMURA Masao

  Department of Toxicology, Panapharm Laboratories Co., Ltd.

• KAWASAKI Tsuneshirou

  Asahi Kasei Pharma Corporation

• WAKIGAWA Kouichi

  Asahi Kasei Pharma Corporation

抄録

As part of a safety evaluation of Coenzyme Q₁₀, a subchronic toxicology study was conducted. Coenzyme Q₁₀ was repeatedly administered orally to male and female Crl:CD(SD) rats at daily dose levels of 300, 600 and 1200 mg/kg for 13 weeks. Neither death nor any toxicological signs were observed in any group during the administration period. No change related to the test substance administered was observed in any group with regard to body weight, food consumption, ophthalmoscopy, hematology, blood biochemistry, necropsy, organ weights or histopathology. Based on these results, the non-observed-adverse-effect level (NOAEL) of Coenzyme Q₁₀ was considered to be 1200 mg/kg/day for male and female rats under these study conditions.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 32 (4), 437-448, 2007

  一般社団法人　日本毒性学会

キーワード

• Coenzyme Q10
• Rats
• Subchronic toxicology

詳細情報

• CRID: 1390282679877281024
• NII論文ID: 110006420619
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.32.437
• ISSN: 18803989
• ISSN: 03881350
• NDL書誌ID: 8981738
• Web Site: http://id.ndl.go.jp/bib/8981738
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8981738
• Web Site: http://www.jstage.jst.go.jp/article/jts/32/4/32_4_437/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008098183
• 本文言語コード: en
• データソース種別:
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