口腔領域に発現した腺様扁平上皮癌の1例 : 病理組織学的ならびに免疫組織化学的検討 A Case of Oral Adenoid Squamous Cell Carcinoma : Histopathological and Immunohistochemical Studies

66歳,男性の右側舌に発現した腺様扁平上皮癌について,病理組織学的ならびに免疫組織化学的研究な検討を行った.病理組織学的には,細胞間橋,角化や扁平上皮の増殖を示さない立方形の腫瘍細胞が腺管様構造を呈していた.また,アルシアンブル-(AB)染色,ムチカルミン(MC)染色,PAS染色にそれぞれ陰性であった.さらに,免疫組織化学的には,腫瘍細胞はサイトケラチン(CK),ビメンチン(VM)に陽性であったが,上皮膜抗原(EMA)や第VIII(FVIII)には陰性であった.以上のことから,本腫瘍は扁平上皮癌細胞の変性と棘融解によって生じたものと思われた.

We reported a case of adenoid squamous cell carcinoma manifested in the tongue of a 66-year-old man along with its histopathological and immunohistochemical findings. Histopathological examination revealed that almost the entire part of the neoplasm was characterized by pseudoglandular structures lined by cuboidal cells lacking intercellular bridges, keratinization, or other features of a squamous growth. Alucian blue (AB), mucicarmin (MC), and periodic acid schiff (PAS) stains failed to demonstrate epithelial mucin in the cytoplasm of the cuboidal cells or intraluminal substance. Immunohistochemical staining showed positive reactions against antibodies to cytokeratin (CK) and vimentin (VM), and no reaction with antibodies to epithelial membrane antigen (EMA) and factor VIII related antigen (FVIII). These findings suggested that this tumor involved the acantholysis and degeneration of a squamous cell carcinoma.