S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina

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著者

    • Jung Hyun Jun JUNG Hyun Jun
    • Department of Microbiology & Immunology, School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University
    • Park Keunnam PARK Keunnam
    • Department of Microbiology & Immunology, School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University
    • KIM Hyun Soo
    • The Center for Traditional Microorganism Resources (TMR), Keimyung University
    • YEO Soo-Hwan
    • Rural Resources Development Institute, National Institute of Agricultural Science and Technology, Rural Development Administration
    • LEE Dong Gun
    • Department of Microbiology & Immunology, School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University

抄録

Amentoflavone, which is a biflavone derived from various plants, has been known to possess various biological activities including anti-tumor and anti-inflammatory activity. In the previous study, we reported antifungal effect of amentoflavone isolated from an ethyl acetate extract of Selaginella tamariscina on human pathogenic fungi. Amentoflavone significantly inhibited the growth of fungal cells without hemolysis of human erythrocytes. In the present study, we investigated antifungal acting mode of amentoflavone in human pathogenic yeast Candida albicans. Anticandidal activity was exerted in an energy-independent manner presented by an antifungal assay in the presence of NaN3, which is ATP-depleting agent as a metabolic inhibitor. To investigate the effects of amentoflavone on cellular physiology in C. albicans, we performed cell cycle analysis, and the analysis showed that amentoflavone significantly arrested cell cycles during the S-phase. These results demonstrated that amentoflavone has potent anticandidal activity with significant physiological changes inducing S-phase arrest in intracellular environment. Therefore, amentoflavone may be applied to a lead compound for the development of therapeutic agents, which can treat candidiasis resulted from candidal infections.

収録刊行物

  • Biological & pharmaceutical bulletin

    Biological & pharmaceutical bulletin 30(10), 1969-1971, 2007-10-01

    公益社団法人日本薬学会

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各種コード

  • NII論文ID(NAID)
    110006436387
  • NII書誌ID(NCID)
    AA10885497
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    09186158
  • NDL 記事登録ID
    8919653
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-V41
  • データ提供元
    CJP書誌  NDL  NII-ELS  J-STAGE 
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