Resistance to Ara-C up-regulates the activation of NF-κB, telomerase activity and Fas expression in NALM-6 cells

• Kanno Syu-ichi

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• Hiura Takako

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• Shouji Ai

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• Osanai Yuu

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• Ujibe Mayuko

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• Ishikawa Masaaki

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

書誌事項

タイトル別名

• Resistance to Ara-C Up-Regulates the Activation of NF-.KAPPA.B, Telomerase Activity and Fas Expression in NALM-6 Cells
• Resistance to Ara C up regulates the activation of NF kB telomerase activity and Fas expression in NALM 6 cells

抄録

Cytosine arabinoside (1-β-D-arabinofuranosylcytosine; Ara-C) is the most important antimetabolite used to induce remission in acute leukemia, but cellular resistance to Ara-C reflects a poor prognosis in cancer chemotherapy. To further investigate the mechanisms of resistance to Ara-C, we have established Ara-C-resistant NALM-6 cells. The activation of nuclear factor κB (NF-κB) was accompanied by the acquisition of Ara-C resistance. Telomerase activity has also increased with the acquisition of Ara-C resistance. The expression of Bid, Bax, or p53 proteins have been shown to increase correlated with the acquisition of Ara-C resistance. In contrast to the increase in these proteins, Bcl-2, Bcl-x, and Bag-1 proteins remained unchanged with the acquisition of Ara-C resistance. Fas expression increased with the acquisition of Ara-C resistance in the late stage. The induction of apoptosis and reduction of cell viability by cytotoxic anti-Fas antibody was more susceptible in resistant cells than parental cells. In conclusion, this report has shown that resistance to Ara-C up-regulates the activation of NF-κB, telomerase activity and Fas expression.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 30 (11), 2069-2074, 2007

  公益社団法人 日本薬学会

キーワード

• 1-β-<small>D</small>-arabinofuranosylcytosine
• resistance
• nuclear factor κB
• telomerase
• Fas
• p53

詳細情報

• CRID: 1390001204626868736
• NII論文ID: 110006473484
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.30.2069
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 8965490
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8965490
• Web Site: http://www.jstage.jst.go.jp/article/bpb/30/11/30_11_2069/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008115433
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可