Mutations Induced by Oxidized DNA Precursors and Their Prevention by Nucleotide Pool Sanitization Enzymes

• Kamiya Hiroyuki

  Faculty of Pharmaceutical Sciences, Hokkaido University

抄録

Base oxidation occurs in the cellular nucleotide pool as well as in DNA, and the oxidized DNA precursors induce mutagenic events. 8-Hydroxy-dGTP (8-OH-dGTP) and 2-hydroxy-dATP (2-OH-dATP) have been identified as the major products of in vitro oxidation reactions with Fe²⁺. The mutagenic potentials of many oxidized DNA precursors have been examined in various experimental systems. Accumulating evidence indicates the importance of 8-OH-dGTP and 2-OH-dATP in the mutation process. In addition, nucleotide pool sanitization enzymes, such as MutT and MTH1, have been identified as a defense against the mutagenesis induced by these oxidized DNA precursors. In this review, the mutagenicities of 8-OH-dGTP and 2-OH-dATP and the functions of MutT-type nucleotide pool sanitization enzymes will be summarized.<br>

収録刊行物

• Genes and Environment

  Genes and Environment 29 (4), 133-140, 2007

  日本環境変異原学会

キーワード

• oxidized DNA precursor
• 8-hydroxy-dGTP
• 2-hydroxy-dATP
• nucleotide pool sanitization enzyme

詳細情報

• CRID: 1390282680232852352
• NII論文ID: 110006474277
• NII書誌ID: AA1212552X
• DOI: 10.3123/jemsge.29.133
• COI: 1:CAS:528:DC%2BD1cXhtlSju7o%3D
• ISSN: 18807062
• ISSN: 18807046
• HANDLE: 2115/34644
• NDL書誌ID: 9282470
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9282470
• Web Site: https://search.jamas.or.jp/link/ui/2008186214
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • NDL
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  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可