Ascorbate Analogs for Use in Medical Imaging : Synthesis and Radical Scavenging Activity of 5-O-(4'-Iodobenzyl)-L-ascorbic Acid

Abstract

As part of our program to develop potential imaging agents for ascorbate bioactivity in the brain, 5-O-(4'-iodobenzyl)-L-ascorbic acid was prepared through a seven-step sequence which involved C_5-O-alkylation with p-iodobenzyl bromide in the presence of Ag_2O and CaSO_4 as the key step, starting from L-ascorbic acid. The scavenging activity of the p-iodobenzylated analog against 2, 2-diphenyl-1-picrylhyrazyl (DPPH) radical was almost the same as that of L-ascorbic acid itself.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 55(12), 1700-1703, 2007-12-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  26

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Codes

  • NII Article ID (NAID) :
    110006532110
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    ART
  • ISSN :
    00092363
  • NDL Article ID :
    9273894
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.55.1700
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE