Synthesis and HIV-1 Integrase Inhibition of Novel Bis- or Tetra-Coumarin Analogues

    • CHIANG Chih-Chia
    • Department of Applied Chemistry and Materials Science, Institute of Technology, National Defense University
    • TSAI Hou-Jen
    • Department of Applied Chemistry and Materials Science, Institute of Technology, National Defense University
    • HSU Ling-Yih
    • Department of Biological Science and Technology, China Institute of Technology

Abstract

Present studies were undertaken on the preparation of synthetic analogues of bis- or tetra-coumarins and their activity against HIV-1 integrase (HIV-1 IN). Among these coumarin analogues, compounds 14, 16 and 18 were found to be potent molecules against HIV-1 IN at IC_<50> values of 0.96, 0.58, and 0.49 μM, respectively. The results provided a tool for guiding the further design of more potent antiviral agents and for predicting the affinity of related compounds.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 55(12), 1740-1743, 2007-12-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  21

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Codes

  • NII Article ID (NAID) :
    110006532118
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    NOT
  • ISSN :
    00092363
  • NDL Article ID :
    9274079
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.55.1740
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE