Structural Development of Liver X Receptor (LXR) Antagonists Derived from Thalidomide-Related Glucosidase Inhibitors

Abstract

Following our previous discovery of LXR antagonistic activity of 2'-substituted phenylphthalimides derived from thalidomide-related glucosidase inhibitors, structure-activity studies and further structural development led to 5-chloro-N-2'-n-pentylphenyl-1, 3-dithiophthalimide (5CPPSS-50), with IC_<50> values of about 10 and 13 μM for LXRα and LXRβ, respectively.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 55(12), 1750-1754, 2007-12-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  23

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Codes

  • NII Article ID (NAID) :
    110006532121
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    NOT
  • ISSN :
    00092363
  • NDL Article ID :
    9274117
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.55.1750
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE