Anti-diabetic Activity of Methanol Leaf Extract of Costus pictus D. DON in Alloxan-induced Diabetic Rats
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- Jothivel Nandhakumar
- Department of Pharmaceutics, Nandha College of Pharmacy
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- Ponnusamy Sethumathi Pudhupalayam
- Department of Pharmaceutics, Nandha College of Pharmacy
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- Appachi Malini
- Department of Biochemistry, Maharaja College for Women
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- Singaravel Sengottuvelu
- Department of Pharmaceutics, Nandha College of Pharmacy
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- Rasilingam Duraisamy
- Department of Pharmaceutics, Nandha College of Pharmacy
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- Deivasigamani Karthikeyan
- Department of Pharmaceutics, Nandha College of Pharmacy
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- Thangavel Sivakumar
- Department of Pharmaceutics, Nandha College of Pharmacy
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The methanol extract of Costus pictus (C. pictus) D. DON (Family: Zingiberaceae) leaf was investigated for its anti-diabetic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of single doses of alloxan monohydrate (120 mg/kg, i.p.). The methanol extract of C. pictus (MECP) at a dose of 120 mg/kg, p.o. was administered as single dose per day to diabetes-induced rats for a period of 21 days. The effect of MECP leaf extract on blood glucose, plasma insulin, serum lipid profile [cholesterol, triglycerides, phospholipids, very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL)], serum enzymes [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), alkaline phosphatase (ALP)], total protein, and liver glycogen were measured in the diabetic rats. Histopathological studies of liver, pancreas and kidney were also carried out. MECP elicited significant (p<0.001) reductions of blood glucose, lipid parameters except HDL, and serum enzymes and significantly (p<0.001) increased HDL level. MECP also caused significant (p<0.001) increases in plasma insulin levels in the diabetic rats. Furthermore, MECP significantly (p<0.05), (p<0.001) increased total protein and liver glycogen in diabetic rats. Histopathological observations revealed that leaf is non-toxic and regenerates the toxic effect of alloxan. From the above results, it is concluded that MECP possesses significant anti-diabetic effects in alloxan-induced diabetic rats.
収録刊行物
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- JOURNAL OF HEALTH SCIENCE
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JOURNAL OF HEALTH SCIENCE 53 (6), 655-663, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679473750912
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- NII論文ID
- 110006545931
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- NII書誌ID
- AA11316464
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- ISSN
- 13475207
- 13449702
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- NDL書誌ID
- 9275358
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可