軟骨異栄養性犬種の変性髄核における増強したX型コラーゲン発現

DOI 日本農学文献記事索引 Web Site Web Site 被引用文献1件 参考文献40件
  • ITOH Hisanori
    Division of Veterinary Surgery, Nippon Veterinary and Animal Science University, School of Veterinary Medicine
  • ASOU Yoshinori
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University
  • HARA Yasushi
    Division of Veterinary Surgery, Nippon Veterinary and Animal Science University, School of Veterinary Medicine
  • HARO Hirotaka
    Department of Orthopaedic Surgery, Graduate School of Medicine, University of Yamanashi
  • SHINOMIYA Kenichi
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University
  • TAGAWA Masahiro
    Division of Veterinary Surgery, Nippon Veterinary and Animal Science University, School of Veterinary Medicine

書誌事項

タイトル別名
  • Enhanced Type X Collagen Expression in the Extruded Nucleus Pulposus of the Chondrodystrophoid Dog
  • Surgery: Enhanced type X collagen expression in the extruded nucleus pulposus of the chondrodystrophoid dog

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The causes of early degeneration and calcification of the nucleus pulposus in the chondrodystrophoid dog are poorly understood, and the underlying molecular mechanism of this process has not yet been clearly defined. Type X collagen is one of the key molecules in endochondral bone growth and development, especially matrix calcification. The relationship between type X collagen and disc degeneration and calcification in chondrodystrophoid dogs has not yet been studied. We analyzed the expression of type X collagen in degeneration and calcification of the intervertebral disc in chondrodystrophoid dogs, using type X collagen immunohistochemistry. Control intervertebral discs were collected from five dogs (4 female, 1 male, average age 1.3 years, beagle breed). Degenerated intervertebral discs were surgically removed from 11 canine patients with intervertebral disc extrusion (1 female, 10 male, average age 5.1 years, dachshund breed) in Nippon Veterinary and Animal Science University. All extruded disc samples showed hypertrophic changes and clustering of cells, typical features observed in the degenerated nucleus pulposus. The relative expression of type X collagen in the degenerated nucleus pulposus (84.3 ± 11.0%) was significantly increased compared to the control nucleus pulposus (5.4 ± 5.4%). Our findings suggest that type X collagen might contribute to the development of degeneration or calcification in the nucleus pulposus of the chondrodystrophoid dog.<br>

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