Frequencies of PrP Genotypes in Meat Breeds of Japanese Sheep and Trail of Selective Breeding in Experimental Sheep Flock

• OHARA Jiro

  Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University

• TOGARI Tetsuro

  Poultry and Sheep Research Unit, Hokkaido Animal Research Center

• KUROKAWA Aya

  Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University

• MAEDA Junko

  Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University

• ISHIGURO Naotaka

  Laboratory of Food and Environmental Hygiene, Faculty of Applied Biological Science, Gifu University

• FURUOKA Hidefumi

  Department of Pathological Science, Obihiro University of Agriculture and Veterinary Medicine

• HORIUCHI Motohiro

  Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University

Bibliographic Information

Other Title

• 日本の肉用種のヒツジにおけるPrP遺伝子型と実験羊群における選抜育種の試み
• Virology: Frequencies of PrP genotypes in meat breeds of Japanese sheep and trail of selective breeding in experimental sheep flock

Abstract

The selection of sheep with scrapie-resistant PrP genotypes is one of the control measures for transmissible spongiform encephalopathies in ruminants. In this study, we investigated the frequencies of PrP genotypes in meat breeds in Japan. The nationwide surveillance revealed that nearly half of the Suffolk sheep, a major meat breed in Japan, carried scrapie-susceptible AQ/AQ and AQ/VQ genotypes. In addition, the VQ haplotype, which confers high susceptibility to scrapie within sheep, was also found in Poll Dorset sheep. A trial of selective breeding using sires with scrapie-resistant PrP genotypes AQ/AR and AR/AR could raise the ratio of scrapie-resistant sheep from less than 50% to 80% within 3 years. However, the use of sires with the AR/AR genotype and the selection of ewes would be required to achieve a higher ratio of scrapie-resistant sheep.<br>

Journal

• Journal of Veterinary Medical Science

  Journal of Veterinary Medical Science 69 (12), 1325-1329, 2007

  JAPANESE SOCIETY OF VETERINARY SCIENCE

Keywords

• prion
• scrapie
• transmissible spongiform encephalopathy

Details

• CRID: 1390001206427983744
• NII Article ID: 110006569963
• NII Book ID: AA10796138
• DOI: 10.1292/jvms.69.1325
• ISSN: 13477439
• ISSN: 09167250
• NDL BIB ID: 9319245
• Web Site: https://agriknowledge.affrc.go.jp/RN/2010760103
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9319245
• Web Site: http://www.jstage.jst.go.jp/article/jvms/69/12/69_12_1325/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008105922
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed