The Enantioselective Total Synthesis of a β-Carboline Alkaloid, (S)-(-)-Dichotomine C(Communication to the Editor)

    • OMURA Kana
    • Graduate School of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
    • CHOSHI Tominari
    • Graduate School of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
    • WATANABE Shiroh
    • Graduate School of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
    • SATOH Yuhsuke
    • Graduate School of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
    • NOBUHIRO Junko
    • Graduate School of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
    • HIBINO Satoshi
    • Graduate School of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

Abstract

The first enantioselective synthesis of a β-carboline alkaloid, dichotomine C, possessing antiallergic effects, was achieved by constructing a β-carboline framework based on the microwave-assisted thermal electrocyclic reaction of a 1-azahexatriene system, followed by the Sharpless asymmetric dihydroxylation.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 56(2), 237-238, 2008-02-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  13

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Codes

  • NII Article ID (NAID) :
    110006570610
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    SHO
  • ISSN :
    00092363
  • DOI :
    10.1248/cpb.56.237
  • Databases :
    CJP  NII-ELS  J-STAGE