Parathyroid Hormone and Vitamin D Levels are Independently Associated With Calcific Aortic Stenosis

• Linhartová Katerina

  Department of Cardiology, Cardiovascular Center, University Hospital Motol Ist Department of Medicine, Charles University School of Medicine Hospital Pilsen

• Veselka Josef

  Department of Cardiology, Cardiovascular Center, University Hospital Motol

• Sterbáková Gabriela

  Ist Department of Medicine, Charles University School of Medicine Hospital Pilsen

• Racek Jaroslav

  Department of Clinical Biochemistry and Haematology, Charles University School of Medicine Hospital Pilsen

• Topolcan Ondrej

  Department of Immunoanalytic Diagnostics, Charles University School of Medicine Hospital Pilsen

• Cerbák Roman

  Center for Transplantation and Cardiovascular Sugery

Abstract

Background In calcific aortic valve disease, the early lesion is similar to atherosclerotic plaque, but later calcification prevails. Parathyroid hormone (PTH) and vitamin D are the principal calcium pool regulators, so the present study was designed to assess their association with aortic stenosis (AS) in patients with significant coronary artery disease (CAD), and preserved renal function. Methods and Results The 122 consecutive patients with AS (mean gradient ≥30 mmHg) plus CAD, and 101 patients with nonobstructive aortic sclerosis (mean gradient ≤10 mmHg) plus CAD, as controls, were prospectively enrolled. The AS patients were older (71±7 vs 66±7 years; p<0.001), had higher serum intact (i)PTH (51.4 [39-70] vs 37.4 [27-50] pg/ml; p<0.001), and lower plasma vitamin D (32.0 [25-40] vs 35.8 [27-55] nmol/L; p=0.003) levels than those with aortic sclerosis. The groups did not differ significantly in creatinine level (93 [82-105] vs 96 [85-107] μmol/L, p=0.19), calcium - phosphate product, occurrence of hypertension, smoking, diabetes, dyslipidemia, or body mass index. The iPTH (odds ratio (OR) 1.04, 95% confidence interval (CI) 1.02-1.05; p<0.001) and vitamin D levels (OR 0.97, 95% CI 0.95-0.99; p=0.003) were independently associated with AS. Conclusion Higher serum iPTH with lower vitamin D levels were independently associated with calcific AS in CAD patients. (Circ J 2008; 72: 245 - 250)<br>

Journal

• Circulation Journal

  Circulation Journal 72 (2), 245-250, 2008

  The Japanese Circulation Society

Keywords

• Aortic stenosis
• Calcium
• Coronary artery disease
• Valvular disease

Details

• CRID: 1390001205104448256
• NII Article ID: 110006571051
• NII Book ID: AA11591968
• DOI: 10.1253/circj.72.245
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/72/2/72_2_245/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008158698
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed