Creation of a composite of collagen and OCP crystals with large morphological anisotropy

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Collagen and octacalcium phosphate (OCP) crystals of micrometer size with anisotropic morphology were combined under physiological temperature and pH. OCP crystals elongated in the c-axis direction were grown in a reaction chamber where diffusion was controlled by a cation selective membrane. The size of crystal used was 40-50 μm in length, about 2 μm in width and aspect ratio of around 20-25. Atelocollagen was reconstituted and cross-linked in the presence of the crystals at 37°C for 20-48 h under stirring. Despite stirring and mixing during fabrication process, the long crystals assembled with reconstituted collagen fibers and arranged more or less parallel to each other along the collagen fibers. This suggested that OCP crystals and collagen fibers assembled through some interaction, by which crystals stayed on/between collagen fibers during fabrication process. Collagen content of resultant composites was arbitrarily changeable in the range of 20-90% by weight. Thus, the composite of long OCP crystals and collagen was newly designed for future application as a bone substitute material.<br>

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