抗菌薬併用におけるｐｏｓｔａｎｔｉｂｉｏｔｉｃ　ｅｆｆｅｃｔの基礎的検討―Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ　ａｕｒｅｕｓ　ＦＤＡ２０９Ｐへのペニシリンとゲンタマイシン併用の場合―

DOI NDLデジタルコレクション 参考文献31件

書誌事項

タイトル別名
  • Postantibiotic Effect of Penicillin plus Gentamicin on Staphylococcus aureus FDA209P In Vitro
  • on Staphylococcus aureus FDA209P InVitro
  • -Staphylococcus aureus FDA209P へのペニシリンとゲンタマイシン併用の場合-

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抄録

Antibiotic combinations are frequently used to provide broad-spectrum empiric coverage for serious infections,and in critical conditions before confirmatory diagnosis.Up till now,studies on antibiotic combinations have mainly focused on their bactericidal and inhibitory activities and few have investigated the postantibiotic effect (PAE) of such combinations.However,it is important to determine the PAE since it is a factor that influences the antibiotic dosing interval.In the present study,we investigated the PAE of penicillin G plus gentamicin on Staphylococcus aureus FDA 209 P in vitro .The results showed that the combination of penicillin G and gentamicin provided a more prolonged PAE,with more rapid killing than penicillin G or gentamicin alone.

収録刊行物

  • 医療薬学

    医療薬学 34 (2), 143-147, 2008

    一般社団法人日本医療薬学会

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