Polymer-Like Polyphenols of Black Tea and Their Lipase and Amylase Inhibitory Activities
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- Kusano Rie
- Graduate School of Biomedical Sciences, Nagasaki University
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- Andou Hisashi
- Graduate School of Biomedical Sciences, Nagasaki University
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- Fujieda Miho
- Graduate School of Biomedical Sciences, Nagasaki University
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- Tanaka Takashi
- Graduate School of Biomedical Sciences, Nagasaki University
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- Matsuo Yosuke
- Graduate School of Biomedical Sciences, Nagasaki University
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- Kouno Isao
- Graduate School of Biomedical Sciences, Nagasaki University
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抄録
Lipase and amylase inhibitory activities of black tea were examined. After solvent partitioning of a black tea extract with the ethyl acetate and n-butanol, the two soluble fractions showed comparable inhibitory activities. Activity in the ethyl acetate fraction was mainly attributable to polyphenols with low-molecular weights, such as theaflavin gallates. On the other hand, the active substance in the n-butanol layer was ascertained to be a polymer-like substance. 1H- and 13C-NMR spectra showed signals arising from the flavan A-ring and galloyl groups, although signals due to flavan B-rings were not detected, suggesting that the polymer-like substances were generated by oxidative condensation of flavan B-rings, a result which was previously deduced from our results of in vitro catechin oxidation experiments. Enzymatic oxidation of epicatechin 3-O-gallate produced a similar polymer-like substance and suggested that condensation between a B-ring and galloyl groups was involved in the polymerization reaction.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 56 (3), 266-272, 2008
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679145737856
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- NII論文ID
- 110006622627
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- HANDLE
- 10069/17916
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- NDL書誌ID
- 9394378
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可