Inhibitory Effects of Ginseng Total Saponins on Behavioral Sensitization and Dopamine Release Induced by Cocaine

DOI Web Site Web Site 参考文献95件
  • Lee BomBi
    Department of Neurobiology, Division of Neuroscience, Children's Hospital and Harvard Medical School
  • Yang Chae Ha
    Department of Physiology, College of Oriental Medicine, Daegu Haany University
  • Hahm Dae-Hyun
    Acupuncture and Meridianology Scientific Research Center, Kyung Hee University
  • Lee Hye-Jung
    Acupuncture and Meridianology Scientific Research Center, Kyung Hee University
  • Han Seung-Moo
    Department of Biomedical Engineering, Kyung Hee University
  • Kim Kyung-Soo
    Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
  • Shim Insop
    Department of Integrative Medicine, College of Medicine, The Catholic University of Korea

この論文をさがす

抄録

Many studies have suggested that the behavioral and reinforcing effects of cocaine can be mediated by the central dopaminergic systems. It has been shown that repeated injections of cocaine produce an increase in locomotor activity, the expression of the immediate-early gene, c-fos, and the release of dopamine (DA) in the nucleus accumbens (NAc), which is one of the main dopaminergic terminal areas. Several studies have shown that behavioral activation and changes in extracellular dopamine levels in the central nervous system induced by psychomotor stimulants are prevented by ginseng total saponins (GTS). In order to investigate the effects of GTS on the repeated cocaine-induced behavioral and neurochemical alterations, we examined the influence of GTS on the cocaine-induced behavioral sensitization and on c-Fos expression in the brain using immunohistochemistry in rats repeatedly treated with cocaine. We also examined the effect of GTS on cocaine-induced dopamine release in the NAc of freely moving rats repeatedly treated with cocaine using an in vivo microdialysis technique. Pretreatment with GTS (100, 200, 400 mg/kg, i.p.) 30 min before the daily injections of cocaine (15 mg/kg, i.p.) significantly inhibited the repeated cocaine-induced increase in locomotor activity as well as the c-Fos expression in the core and shell in a dose-dependent manner. Also, pretreatment with GTS significantly decreased the repeated cocaine-induced increase in dopamine release in the NAc. Our data demonstrate that the inhibitory effects of GTS on the repeated cocaine-induced behavioral sensitization were closely associated with the reduction of dopamine release and the postsynaptic neuronal activity. The results of the present study suggest that GTS may be effective for inhibiting the behavioral effects of cocaine by possibly modulating the central dopaminergic system. These results also suggest that GTS may prove to be a useful therapeutic agent for cocaine addiction.

収録刊行物

参考文献 (95)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ