Effect of Tangzhiqing on Glucose and Lipid Metabolism in Genetically Type 2 Diabetes KK-Ay Mice

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Abstract

The hypoglycemic and hypolipidemic effects of Tangzhiqing (abbreviated TZ) a mixture of Mulberry Leaf, Lotus Leaf, Danshen Root, and Hawthorn Leaf, were investigated in KK-Ay mice, an animal model of type 2 diabetes. TZ reduced blood glucose, total cholesterol, and triglyceride levels of KK-Ay mice at 4 weeks after oral administration. TZ also improved sucrose or maltose tolerance. Maltase activity in small intestine significantly decreased in the TZ-treated KK-Ay mice. These results support the hypothesis that TZ improves glucose metabolism by reducing α-glycosidase activity. Therefore TZ might have beneficial effects on hyperglycemia and hyperlipidemia in type 2 diabetes.

Journal

Journal of health science   [List of Volumes]

Journal of health science 54(2), 203-206, 2008-04-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  13

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Codes

  • NII Article ID (NAID) :
    110006649671
  • NII NACSIS-CAT ID (NCID) :
    AA11316464
  • Text Lang :
    ENG
  • Article Type :
    SHO
  • ISSN :
    13449702
  • NDL Article ID :
    9441341
  • NDL Source Classification :
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL Call No. :
    Z54-J464
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE