Effect of Different Formulation Variables on Some Particle Characteristics of Poly (DL-lactide-co-glycolide) Nanoparticles
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- MONDAL Nita
- Department of Pharmaceutical Technology, Jadavpur University
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- SAMANTA Arnab
- Netaji Subhas Chandra Bose Institute of Pharmacy
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- PAL Tapan Kumar
- Department of Pharmaceutical Technology, Jadavpur University
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- GHOSAL Saroj Kumar
- Department of Pharmaceutical Technology, Jadavpur University
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Abstract
This study investigates the effect of some formulation variables on particulate characteristics of poly (DL-lactide-co-glycolide) (PLGA) copolymer nanoparticles by applying 23 factorial design and response surface methodology (RSM). Nanoparticles were prepared by solvent displacement technique. Initially, appropriate formulation factors for elaboration of polymeric particles were selected by screening. A 23 full factorial design was employed to evaluate the influence of three formulation variables, polymer concentration (X1), dispersant concentration (X2) and phase volume ratio (X3) on the percentage of total particles at submicron range (Y1), mean diameter (Y2) and specific surface area (Y3) as particle characteristics. The results showed that all the three variables had significant influence on mean diameter of particles and amount of particles at submicron range. Simultaneous change of polymer concentration and dispersant concentration had significant effect on specific surface area of particles. Span value as an index of polydispersity indicated uniformity in particle size distribution.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 128 (4), 595-601, 2008-04-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282681104321536
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- NII Article ID
- 110006656196
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 9463259
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed