8 生理活性アミノアシルユラシル類(イソビラルジイン、ポリオキシン)の合成研究

DOI

書誌事項

タイトル別名
  • 8 SYNTHETIC STUDIES OF BIOLOGICALLY ACTIVE AMINOACYLURACIL DERIVATIVES : ISOWILLARDIINE AND POLYOXINS

抄録

The present report deals with the synthesis of isowillardiine (II) and the polyoxin skeleton which have the α-aminouracil structure in common, by the four-component (aldehyde, isocyanide, amine, and organic oxyacid) condensation (Ugi reaction). This reaction permited us to synthesize the above structure (in their protected forms) in one step starting from the corresponding aldehyde. Removal of the protecting group in VIII under conditions of 9N HCl-48 hr afforded isowillardiine, whereas many attempts at complete removal of the protection to XVI is not rewarding, yet.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390282681051442560
  • NII論文ID
    110006677895
  • DOI
    10.24496/tennenyuki.20.0_53
  • ISSN
    24331856
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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