58 セレチウムアルカロイドの合成研究

DOI

書誌事項

タイトル別名
  • 58 Synthetic Studies on Sceletium Alkaloids

抄録

For the purpose of synthesizing the title alkaloids starting from 2-aryl-5,5-ethylenedioxycyclohexanone (5b or 21), alkylation of 2-arylcyclohexanone (5a) in the presence of a phase transfer catalyst was examined. Namely, 5a was treated with alkyl halides in 50% aq.NaOH and benzene in the presence of 18-crown-6 to give regioselectively 2-alkyl-2-arylcyclohexanones (6) in moderate yields. The similar reaction of 5b or 21 with allyl bromide afforded 2-allyl-2-aryl-5,5-ethylenedioxycyclohexanone (9) or (22) in 69.5 or 60% yield. By use of 9 or 22, synthesis of (±)-mesembrine (1) and (±)-dihydromaritidine (17) or (±)-joubertiamine (2) was accomplished.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390001206074551808
  • NII論文ID
    110006678262
  • DOI
    10.24496/tennenyuki.24.0_445
  • ISSN
    24331856
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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