82(P2-12) 放線菌の生産する新規テルペンアルカロイド、アルテミシジンの構造(ポスター発表の部)  [in Japanese] 82(P2-12) STRUCTURE DETERMINATION OF A NEW TERPENE ALKALOID PRODUCED BY AN ACTINOMYCETE  [in Japanese]

Screening of new insecticidal and acaricidal antibiotics was carried out with reference to anti-brine shrimp activity from actinomycete strains. As a result, one actinomycete isolates identified as Streptomyces sioyaensis SA-1758 was found to produce a new substance, altemicidin. Altemicidin was purified by activated charcoal, Diaion CHP-20P and Sephadex LH-20 column chromatographies. The molecular formula was determined as C_<13>H_<20>N_4O_7S by elemental analysis, mass spectra and ^<13>C NMR spectrum. The structure was determined to be (1R,2S,3aR,7aS)-4-carbamoy1-2-hydroxy-6-methyl-1-(sulfamoylacetamido)-2,3,3a,6,7,7a-hexahydro-6-azaindene-1-carboxylic acid by the spectroscopic analysis and X-ray crystallographic analysis of its derivatives. Altemicidin belongs to the monoterpene alkaloid. Altemicidin showed not only acaricidal activity but also antitumor activity. And the compound showed no antimicrobial activity.