56 ユリ科ツルボ亜科植物の生理活性成分研究Cyclic AMP phosphodiesterase阻害活性を有する新規トリテルペン配糖体の構造(ポスター発表の部)

DOI

書誌事項

タイトル別名
  • 56 STUDIES ON THE BIOACTIVE COMPONENTS FROM SCILLOIDEAE PLANTS IN LILIACEAE; STRUCTURES OF NOVEL TRITERPENE GLYCOSIDES AND THEIR INHIBITORY ACTIVITY ON CYCLIC AMP PHOSPHODIESTERASE

抄録

As part of a systematic study on the bioactive substances from Liliaceae plants, we have investigated six plants belonging to the subfamily Scilloideae in the Liliaceae. Scilla peruviana yielded three novel lanosterol trisaccharides, peruvianosides A (1), B (2) and C (3). Their structures were established by the concerted use of modern two-dimentional NMR techniques. Peruvianoside A (1)-C (3) are unique in structure having the rearranged lanostane skeleton. Futher, S. peruviana, Eucomis bicolor and Chionodoxa gigantea were shown to contain novel lanosterol penta- and hexasaccharides with the side-chain being modified to form the spiro-lactone group, scillasaponins A (4), B (5) and C (6), and norlanosterols (7-12). Scillasaponins may be the biological precursors of the norlanosterols. The structures of the new cholestane glycosides (13-22) from Ornithogalum saundersiae and O. thyrsoides, and steroidal saponins from Camassia cusickii (23 nad 24) are briefly discussed. The cholestane glycosides (13 - 15) have the migrated side-chain structures. The compounds isolated were evaluated for cyclic AMP phosphodiesterase inhibitory activity as the first screening test for finding new medicinal materials. Almost all the triterpene glycosides showed medium inhibitory activity, and the cholestane glycoside (18) and steroidal saponin (24) showed potent inhibitory activity.

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詳細情報 詳細情報について

  • CRID
    1390001206079364992
  • NII論文ID
    110006679117
  • DOI
    10.24496/tennenyuki.34.0_432
  • ISSN
    24331856
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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