78 新規なフィブリノーゲンレセプター阻害物質Tetrafibricinの構造(ポスター発表の部)
書誌事項
- タイトル別名
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- 78 Structural determination of a novel fibrinogen receptor antagonist, tetrafibricin
抄録
In our screening program for fibrinogen receptor antagonists of microbial origin, we isolated a novel fibrinogen receptor antagonist, tetrafibricin, from the culture broth of Streptomyces neyagawaensis NR0577. Tetrafibricin was purified by Diaion HP-21 adsorption, MeOH extraction, Diaion CHP-20P column chromatography, prep-HPLC (C_<18>), Diaion CHP-20P and Toyopearl HW-40 SF column chromatography. The molecular formula was determined to be C_<41>H_<67>NO_<13> by HR FAB-MS and NMR data. The structure of tetrafibricin was determined to be 1 by various 2D-NMR experiments on tetrafibricin and N-acetyl-dihydrotetrafibricin methyl ester (4). Tetrafibricin strongly inhibited the binding of fibrinogen to its receptors in the GPIIb/IIIa solid phase assay with an IC_<50>of 46 nM and it also inhibited ADP-, collagenor thrombin-induced aggregation of human platelets with IC_<50>s of 5.6, 11.0, 7.6μM, respectively.
収録刊行物
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- 天然有機化合物討論会講演要旨集
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天然有機化合物討論会講演要旨集 34 (0), 604-611, 1992
天然有機化合物討論会実行委員会
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詳細情報 詳細情報について
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- CRID
- 1390282681054408576
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- NII論文ID
- 110006679139
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- ISSN
- 24331856
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可