Biological Effects of a Sulfated-Polysaccharide Isolated from the Marine Red Algae Champia feldmannii
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- Assreuy Ana Maria Sampaio
- Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará
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- Gomes Daniel Magalhães
- Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará
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- da Silva Michelle Soares Josino
- Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará
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- Torres Valeska Martins
- Departamento de Engenharia de Pesca, Universidade Federal do Ceará
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- Siqueira Rômmulo Celly Lima
- Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará
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- Pires Alana de Freitas
- Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará
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- Criddle David Neil
- MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool
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- de Alencar Nylane Maria Nunes
- Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará
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- Cavada Benildo Sousa
- Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará
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- Sampaio Alexandre Holanda
- Departamento de Engenharia de Pesca, Universidade Federal do Ceará
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- Farias Wladimir Ronald Lobo
- Departamento de Engenharia de Pesca, Universidade Federal do Ceará
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Abstract
Sulfated-polysaccharides are exploited as antithrombotic and anticoagulant agents and suggested to be immunostimulants. The sulfated-polysaccharide isolated from the red-marine-algae Champia feldmannii (Cf-PLS) was purified by ion exchange chromatography and tested in experimental protocols of coagulation, inflammation (in Wistar rats) and nociception (in Swiss mice). Cf-PLS was tested i.v. for its anti-inflammatory activity in the paw-edema induced by classical inflammatory stimuli and s.c. for its pro-inflammatory activity in the paw-edema and peritonitis models. The anticoagulant activity was evaluated by the test of partial thromboplastin activation time (aPTT) and the antinociceptive effect in the writhing-test. Cf-PLS was not anti-inflammatory, but rather induced maximal edematogenic activity at 0.9 mg/kg (1.01±0.030×0.06±0.03 ml) compared to controls (0.06±0.03 ml), increased vascular-permeability (38.44±12.63×11.29±3.91 μg/g) and stimulated neutrophil migration (3.348±295×307±99 cells/μl) 1 h after injection. Cf-PLS was also antinociceptive (6.6±1.28×33±1.44 writhes) and extended human plasma coagulation time by 3 times. Our data suggest that this molecule may be an important immunostimulant.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 31 (4), 691-695, 2008
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204626349440
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- NII Article ID
- 110006680508
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 9431772
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed