Beta-Blockade Does Not Alter Plasma Cytokine Concentrations and Ventricular Function in Young Adults With Right Ventricular Dysfunction Secondary to Operated Congenital Heart Disease

• Norozi Kambiz

  Department of Paediatric Cardiology and Intensive Care, Medical School Hannover

• Buchhorn Reiner

  Department of Paediatrics, Caritas Krankenhaus Bad Mergentheim Department of Paediatric Cardiology and Intensive Care, Georg-August-University

• Wessel Armin

  Department of Paediatric Cardiology and Intensive Care, Medical School Hannover

• Bahlmann Jens

  Department of Paediatric Cardiology and Intensive Care, Georg-August-University

• Raab Björn

  Department of Radiology, Georg-August-University

• Geyer Siegfried

  Medical Sociology Unit, Medical School Hannover

• Kuehne Titus

  Department of Congenital Heart Disease and Paediatric Cardiology, German Heart Institute

• Beibei Li

  Universitätsklinik und Poliklinik für Innere Medizin III, Martin-Luther-Universität Halle-Wittenberg

• Werdan Karl

  Universitätsklinik und Poliklinik für Innere Medizin III, Martin-Luther-Universität Halle-Wittenberg

• Loppnow Harald

  Universitätsklinik und Poliklinik für Innere Medizin III, Martin-Luther-Universität Halle-Wittenberg

抄録

Background Right heart failure is a major problem of young adults with congenital heart disease (ACHD) that has been corrected by cardiac surgery. In left ventricular dysfunction (LVD), β-blocker therapy improved cytokine concentrations and clinical status. Thus, the effect of bisoprolol on clinical status and plasma cytokine concentrations in ACHD patients with right heart failure after surgical correction for Tetralogy of Fallot was investigated. Methods and Results A prospective, randomized, double-blind, placebo controlled study for a duration of 6 months was carried out. A total of 34 patients (30.9±9.5 years; New York Heart Association I or II) with brain natriuretic peptide plasma concentrations >100 pg/ml and peak oxygen uptake <25 ml · kg^-1 ·min^-1 were recruited. Bisoprolol did not reduce plasma concentrations of soluble tumor necrosis factor receptors (sTNF-R) and interleukin-6 (IL-6) in ACHD patients (before/after: sTNF-R1: 750±131/802±130; sTNF-R2: 3,693±1,043/4,166±840; IL-6: 12.94±26.03/13.69±16.58 pg/ml). Likewise, peak oxygen uptake, right and left ventricular parameters (determined by magnetic resonance imaging) were not improved by bisoprolol treatment. Conclusion In contrast to previously observed beneficial effect(s) of β-blockade in patients with LVD, there were no beneficial therapeutic effects or cytokine reduction in asymptomatic or minimal symptomatic ACHD patients. These data point to a different pathophysiological role of cytokines in ACHD patients with right ventricular dysfunction, as compared to patients with LVD. (Circ J 2008; 72: 747 - 752)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 72 (5), 747-752, 2008

  一般社団法人 日本循環器学会

キーワード

• Beta-blocker therapy
• Congenital heart defects
• Cytokines
• Heart failure
• Natriuretic peptides

詳細情報

• CRID: 1390282680079163392
• NII論文ID: 110006680553
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.72.747
• COI: 1:STN:280:DC%2BD1c3nvVOntQ%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/72/5/72_5_747/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008234252
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可