Heterogeneous Reduction of Myocardial Oxidative Metabolism in Patients With Ischemic and Dilated Cardiomyopathy Using C-11 Acetate PET

• Wu Yen-Wen

  Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine

• Naya Masanao

  Departments of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University

• Tsukamoto Takahiro

  Departments of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University

• Komatsu Hiroshi

  Departments of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University

• Morita Koichi

  Departments of Nuclear Medicine, Graduate School of Medicine, Hokkaido University

• Yoshinaga Keiichiro

  Departments of Nuclear Medicine, Graduate School of Medicine, Hokkaido University

• Kuge Yuji

  Departments of Nuclear Medicine, Graduate School of Medicine, Hokkaido University

• Tsutsui Hiroyuki

  Departments of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University

• Tamaki Nagara

  Departments of Nuclear Medicine, Graduate School of Medicine, Hokkaido University

抄録

Background The ¹¹C-acetate positron emission tomography can estimate myocardial oxidative metabolism, but previous studies have only evaluated small populations and the difference between ischemic (ICM) and idiopathic dilated cardiomyopathy (DCM) has not been fully investigated. The present aims were to evaluate global and regional myocardial oxidative metabolism in a well-characterized, large population with left ventricular (LV) dysfunction in order to clarify the metabolic differences between ICM and DCM. Methods and Results Seventy-eight patients with ejection fraction (EF) ≤50% (33 ICM; 45 DCM) were compared with 14 healthy controls. Myocardial oxidative metabolism was estimated with a clearance rate constant (K_mono) and the coefficient of variation (CV) of regional K_mono. Patients with LV dysfunction had reduced K_mono and higher CV (p<0.05). In the comparison of oxidative alterations with clinical variables there was a weak correlation between K_mono and LVEF (r=0.27). Although K_mono was reduced in both ICM and DCM, CV was more pronouncedly increased in ICM (p=0.001). In multivariate analysis, the presence of left bundle branch block (LBBB) was an independent predictor of heterogeneous oxidative metabolism in DCM (R²=0.30, p<0.0001). Conclusions Global reduction of myocardial oxidative metabolism occurred in both ICM and DCM. Heterogeneous oxidative metabolism was observed in these patients, especially those with ICM. Furthermore, LBBB was the independent predictor of heterogeneous oxidative metabolism in patients with DCM. (Circ J 2008; 72: 786 - 792)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 72 (5), 786-792, 2008

  一般社団法人 日本循環器学会

キーワード

• Carbon-11 acetate PET
• Dilated cardiomyopathy
• Ischemic cardiomyopathy
• Left ventricular dysfunction
• Myocardial oxidative metabolism

詳細情報

• CRID: 1390282680079167872
• NII論文ID: 110006680559
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.72.786
• COI: 1:STN:280:DC%2BD1c3nvVOmsQ%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• HANDLE: 2115/45964
• Web Site: http://www.jstage.jst.go.jp/article/circj/72/5/72_5_786/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008234258
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • Crossref
  • CiNii Articles
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