2 海洋共生藻由来の超炭素鎖有機分子の構造と機能(口頭発表の部)

• 北 将樹

  名大物質国際研:(現)筑波大学大学院数理物質科学研究科化学専攻

• 大石 奈央

  名大院理

• 小西 香織

  名大院理

• Han Chunguang

  名大院理

• 加藤 彰

  名大院理

• 山野 喜

  名大院理

• Siwu Eric R. O.

  名大院理

• 北村 誠

  名大院理

• 山田 薫

  名大院理

• 上村 大輔

  名大院理

書誌事項

タイトル別名

• 2 Bioactive Secondary Metabolites from Symbiotic Marine Dinoflagellates

抄録

Marine dinoflagellates are a rich source of various biologically and physiologically active secondary metabolites. Among them, large polyol and polyether compounds composed of a long carbon backbone that is highly functionalized by oxygen are some of the most unique and unusual compounds. The true origin of secondary metabolites isolated from marine invertebrates such as sponges, ascidians, nudibranchs, has been suggested to be mostly microorganisms, which are accumulated in the host animals through a symbiotic relationship or a food chain. However, the true physiological functions or roles of polyol compounds in the ecosystem or symbiotic relationship have rarely been clarified. Based on its structural, biological, and conformational diversity and uniqueness, various potential abilities of such polyol compounds are considered, i.e. chemical communication with host animals, defense materials, or nutrient sources. To establish their roles in symbiotic organisms, we have investigated polyol compounds from symbiotic dinoflagellates. Recently, we isolated two novel long carbon-chain polyol compounds, symbiodinolide (1) from Symbiodinium sp., and durinskiol A (2) from the cultured symbiotic dinoflagellate Durinskia sp. Their partial relative stereostructures were elucidated based on 2D-NMR and MS/MS analysis and degraded reactions. Symbiodinolide (1), a 62-membered novel polyol macrolide with a molecular weight of 2,859 mu, exhibited a potent voltage-dependent N-type calcium ion channel-opening activity at 7 nM. Durinskiol A (2) possessed a 6,5,6-bis-spiroacetal ring, two terminal olefins, two sugar units, and six- and seven-membered ether rings. It caused a short body length, abnormal pigment pattern, and pericardiac and yolk-sac edema in zebrafish. We describe here the structure and biological activity of these polyol compounds.

収録刊行物

• 天然有機化合物討論会講演要旨集

  天然有機化合物討論会講演要旨集 49 (0), 7-12, 2007

  天然有機化合物討論会実行委員会

詳細情報

• CRID: 1390282681056360576
• NII論文ID: 110006682732
• DOI: 10.24496/tennenyuki.49.0_7
• ISSN: 24331856
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可