Bioactive Substance from Grifola frondosa (Maitake) Mushroom Inhibits CCAAT Enhancer Binding Protein β and δ Expression on C3H10T1/2 B_2C_1 Adipocyte Cells

    • MINAMINO Katsuhiko
    • Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University
    • YANAGA Yuri
    • Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University
    • OHTSURU Masaru
    • Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University

Abstract

Bioactive compound substances from Grifola frondosa (maitake) inhibited adipocyte differentiation of B_2C_1 preadipocytes. This compound is not related to MAP kinase (ERK1 and ERK2) cascades or β-catenin, which inhibit the expression of Glut4, PPARγ and C/EBPα. The compound reduced the expression time of C/EBPβ and C/EBPδ. These results suggest that the inhibitory action of these bioactive compounds on adipocyte differentiation is exhibited through preadipocytes. They cannot induce the expression of PPARγ or C/EBPα because of the reduced expression time of C/EBPβ and C/EBPδ.

Journal

Journal of nutritional science and vitaminology   [List of Volumes]

Journal of nutritional science and vitaminology 54(3), 250-254, 2008-06  [Table of Contents]

The Vitamin Society of Japan

References:  12

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Codes

  • NII Article ID (NAID) :
    110006792027
  • NII NACSIS-CAT ID (NCID) :
    AA00703822
  • Text Lang :
    ENG
  • Article Type :
    ART
  • ISSN :
    03014800
  • NDL Article ID :
    9544291
  • NDL Source Classification :
    ZR2(科学技術--生物学--生化学)
  • NDL Call No. :
    Z53-B484
  • DOI :
    10.3177/jnsv.54.250
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE