ワルファリンカリウムとブコローム併用による抗凝固作用の薬学的検討

• 浜田 篤秀

  高知大学医学部附属病院薬剤部

• 尾木 恭子

  高知大学医学部附属病院薬剤部

• 見元 尚

  高知大学医学部附属病院薬剤部

• 宮村 充彦

  高知大学医学部附属病院薬剤部

• 京谷 庄二郎

  高知大学医学部附属病院薬剤部

• 西岡 豊

  高知大学医学部附属病院薬剤部

書誌事項

タイトル別名

• Pharmaceutical Study on Anticoagulation in Case of Coadministration of Bucolome and Warfarin Potassium

抄録

To evaluate combination therapy with warfarin potassium (WF) and bucolome (BUC),we assigned patients on warfarin potassium (WF) at Kochi University Medical School Hospital to a group also receiving BUC (BUC-combination group) and a group not receiving BUC (non-combination group),and compared the WF doses and TT values.In each patient,we investigated the doses of WF before and after the start or discontinuation of combination therapy with BUC.There was no significant difference in TT values between the two groups.However,the WF dose in the BUC-combination group was significantly lower than that in the non-combination group.BUC was therefore useful for maintaining anticoagulation activity and decreasing the dose of WF.Furthermore,there was a correlation between the doses of WF before and after the start or discontinuation of combination therapy with BUC in each patient.Based on the regression line obtained using WF doses,in the presence and absence of BUC,the subsequent dose of WF could be predicted at the start or discontinuation of combination therapy with BUC,suggesting that it would be useful in anticoagulation control.

収録刊行物

• 医療薬学

  医療薬学 34 (7), 658-661, 2008

  一般社団法人日本医療薬学会

キーワード

• warfarin
• bucolome
• anticoagulation
• thrombo test
• CYP2C9

詳細情報

• CRID: 1390282679753397376
• NII論文ID: 110006821417
• NII書誌ID: AA11527197
• DOI: 10.5649/jjphcs.34.658
• ISSN: 18821499
• ISSN: 1346342X
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10559434
• Web Site: https://search.jamas.or.jp/link/ui/2009027817
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • NDL-Digital
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可