抄録
【背景】軟部好酸球肉芽腫は境界不鮮明な無痛性腫瘤として認められる.著明な好酸球浸潤が特徴的であり,ステロイド投与で腫瘍は縮小するが,投与を止めると再度増大する難治な疾患である.今回,我々は電子顕微鏡にて軟部好酸球肉芽腫の好酸球の特徴を謂べた.【方法】ステロイド投与前後で耳下部腫瘤に針生検を施行し,採取した組織の特徴を電子顕微鏡で観察した.【結果】ステロイド投与前では肉芽中の好酸球は90%以上細胞膜が破綻していた.細胞間隙にCharcot Lyden crvstal が多数認められた.ステロイド投与後では90%以上の好酸球で崩壊が認められなかった。Charcot Lyden crystalは認められなかった.【結論】軟部好酸球肉芽腫の増悪因子として肉芽内での好酸球の崩壊が示唆された.
Background: Soft tissue eosinophilic granuloma assumes the form of a poorly-demarcated painless mass, and is characterized by marked eosinophil infiltration. Although this tumor decreases in size in response to steroid therapy, it grows again after discontinuation of it, and ultimately proves intractable to treatment. We recently attempted to characterize electron-microscopically the eosinophils in the area affected by soft tissue eosinophilic granuloma. Methods: Needle biopsy of subauricular masses was carried out before and after steroid treatment. The collected tissue was observed under an electron microscope. Results: Before treatment, more than 90% of the eosinophils constituting the granulation tissue had a broken cell membrane. A number of Charcot-Leyden crystals were noted in the intercellular spaces. Following steroid treatment, more than 90% of eosinophils were intact, and Charcot-Leyden crystals were no longer observed. Conclusion: These findings suggest that destruction of eosinophils within granulation tissue aggravates soft tissue eosinophilic granulom.
