Comparison of pharmacological effects of Yanbian Toki, Yamato Toki and Hokkai Toki (Angelicae Radix) on oketsu (blood stagnation) and hie-sho (chilliness) in animal models

    • 範本 文哲 NORIMOTO Hisayoshi
    • クラシエ製薬株式会社評価・分析センター薬理研究テーム Products Evaluation & Quality Analysis Research Laboratories, Kracie Pharma, Ltd.
    • YOSHIDA Kazuo
    • Products Evaluation & Quality Analysis Research Laboratories, Kracie Pharma, Ltd.

    • MORIMOTO Yasuo
    • Products Evaluation & Quality Analysis Research Laboratories, Kracie Pharma, Ltd.

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Abstract

「延辺当帰」は約70年前に大和当帰を日本から中国東北地区に導入したものと言われている。実際,延辺当帰は化学的および遺伝学的に現行品の大和当帰に近似し,そのため大和当帰と同様に生薬原料として利用できることが期待されている。そこで今回,ベタメタゾンによる〓血モデルマウスおよび冷水浸潰による冷え症モデルラットを用い,当帰の代表的な薬理作用(駆〓血作用,冷え症改善作用)について,延辺当帰と大和当帰,および同じく現行品の北海当帰の比較を行った。1)〓血マウスでの末梢血流改善効果 : 3種の当帰工キス(各200 mg/kg)を単回または連続経口投与した群では,末梢血流量はいずれも対照群に比べて有意に増加した。その効果は大和当帰が最も強かったものの,3種の当帰間で明らかな差はなかった。2)冷え症改善効果 : 3種の当帰工キス(各200 mg/kg)を投与した群では,冷水浸漬から解除後の体表温の回復値はいずれも対照群に比べて大きかったが,3種の当帰間では明らかな差は認められなかった。以上の結果から,延辺当帰は現行品の大和および北海当帰と比べて,少なくとも同等の薬理作用を有していると考えられる。

Previous reports suggest that Yanbian Toki (Angelica species of northeast China) may become an alternative resource of Angelicae Radix (Toki) when compared with the Japanese indigenous plants of A. acutiloba Kitagawa (Yamato Toki) and A. acutiloba var. sugiyamae Hikino (Hokkai Toki) in their similar chemical and genetic characteristics. In the present study, the pharmacological effects of Yanbian Toki on oketsu and hie-sho were assessed by using animal models in comparison with Yamato Toki and Hokkai Toki. Oketsu state (stagnation of blood) was induced in mice by a consecutive injection of betamethasone (1.6 mg/kg/day, i.m.). Changes in peripheral blood flow of oketsu mice treated with each Toki extract at a dose of 200 mg/kg were examined both in single and repeated administrations. Yanbian Toki improved the peripheral blood flows of oketsu mice as well as Yamato Toki and Hokkai Toki, and showed no significant statistically differences. In hie-sho (chilliness) model, accomplished by submerging the rats in cold water, the restoration of body surface temperature was accelerated by a single administration of each Toki extract (200 mg/kg). Especially at the initial 5 min, it was significant. Furthermore, the time versus recovery effect was statistically significant in the treatment of Yamato Toki. However, there were no significant differences among them in their recovery effects. In both experiments, among Yanbian Toki, Yamato Toki and Hokkai Toki, there were no significant differences in their effects on oketsu and hie-sho. These results suggested that Yanbian Toki is pharmacologically comparable to Yamato Toki and Hokkai Toki.

Journal

Journal of traditional medicines   [List of Volumes]

Journal of traditional medicines 25(3), 90-94, 2008-07-20  [Table of Contents]

Medical and Pharmaceutical Society for WAKAN-YAKU

References:  18

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Codes

  • NII Article ID (NAID) :
    110006839038
  • NII NACSIS-CAT ID (NCID) :
    AA12035198
  • Text Lang :
    ENG
  • Article Type :
    SHO
  • ISSN :
    18801447
  • NDL Article ID :
    9594461
  • NDL Source Classification :
    ZS51(科学技術--薬学)
  • NDL Call No. :
    Z19-1563
  • Databases :
    CJP  NDL  NII-ELS