Cremophor EL modifies adriamycin-induced action on human leukemia K562 cells

• Matsui, Hiroko

• Sakanashi, Yoko

• Nishimura, Yumiko

• Horimoto, Kanna

• Kanemaru, Kaori

• Ishida, Shiro

• Okano, Yoshiro

• Oyama, Yasuo

書誌事項

タイトル別名

• ヒト白血病K562細胞におけるアドリアマイシン作用のクレモフォールELによる修飾

抄録

Adriamycin and paclitaxel are simultaneously used for cancer treatment in some cases. The formula of paclitaxel contains cremophor EL as a solvent. Since this solvent exerts diverse biological actions, the modification of adriamycin action by cremophor EL has been studied on human leukemia K562 cells. Cremophor EL did not significantly affect the concentration-response relation for antiproliferative action of adriamycin and the cell cycle changed by adriamycin. However, the induction of morphological change by adriamycin was significantly augmented by cremophor EL. The simultaneous application of cremophor EL increased the intensity of fluorescence from adriamycin trapped inside the cells in a concentration-dependent manner, suggesting an increase in intracellular concentration of adriamycin by cremophor EL. Adriamycin alone at concentrations higher than those to completely inhibit the growth induced morphological change in K562 cells. Therefore, cremophor EL may potentiate some of actions induced by adriamycin when adriamycin and paclitaxel are simultaneously applied.

収録刊行物

• Natural Science Research

  Natural Science Research 21 9-17, 2007-12-21

  徳島大学総合科学部

キーワード

• adriamycin
• cremophor EL
• cytotoxicity
• human leukemia K562 cells

詳細情報

• CRID: 1050293633442989056
• NII論文ID: 110006839863
• NII書誌ID: AN10065859
• ISSN: 09146385
• NDL書誌ID: 9315436
• Web Site: http://repo.lib.tokushima-u.ac.jp/117529
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9315436
• 本文言語コード: en
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • NDL
  • CiNii Articles