Effects of Benzo[a]pyrene on Autonomic Nervous System of Coke Oven Workers

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  • Zhang Hong-Mei
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Nie Ji-Sheng
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Wang Fang
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Shi Ying-Tao
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Zhang Ling
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Antonucci Andrea
    Department of Medicine and Science of Ageing, University `G. D' Annuzio of Chieti and Pescara
  • Liu Hui-Jun
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Wang Jing
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Zhao Jie
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Zhang Qin-Li
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Wang Lin-Ping
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Song Jing
    Department of Occupational Health, School of Public Health, Shanxi Medical University
  • Xue Cui-E
    Division of Clinical Hematology Examination, Fenyang College, Shanxi Medical University
  • Gioacchino Mario Di
    Department of Medicine and Science of Ageing, University `G. D' Annuzio of Chieti and Pescara
  • Niu Qiao
    Department of Occupational Health, School of Public Health, Shanxi Medical University

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Abstract

Objectives are to investigate the effects of benzo[a]pyrene (B[a]P) on the autonomic nervous system of coke oven workers. One hundred eighty-four coke oven workers were divided into 3 groups according to their working sites (coke oven bottom group, coke oven side group and coke oven top group), and 93 referents were recruited. B[a]P monitored by air sampling pumps as well as urinary 1-hydroxypyrene (1-OH-Py) was determined by high performance liquid chromatograph with a fluorescence detector (HPLC-FD). The autonomic nervous system (ANS) function was determined by 4 tests: Valsalva Manoeuvre heart rate variation (HR-V), variation of heart rate when breathing deeply (HR-DB), variation of heart rate when instantly standing up (HR-IS, including RR30:15 and RRmax:min) and variation of blood pressure when instantly standing up (BP-IS). The B[a]P mean concentrations in coke oven bottom, coke oven side and coke oven top were 19, 185 and 1,623 ng/m3, respectively. The levels of urinary 1-OH-Py were markedly higher in the 3 exposed groups than that in the referent group (p<0.01). No significant difference was found in each group between smokers and non-smokers (p>0.05). Compared with referents, HR-V decreased significantly in coke oven workers (p<0.01), representing modulation of parasympathetic nervous function. However, no statistical differences were found in HR-DB, RR30:15, RRmax:min and BP-IS between the exposed groups and the control group (p>0.05). HR-V decreased with the increment of 1-OH-Py (p<0.05), and results of multiple linear stepwise regression demonstrated that external exposure level and duration of education entered the HR-V model; age was a significant factor of HR-DB and RRmax:min, but no variable was involved in RR30:15 and BP-IS regression. Benzo[a]pyrene affects the autonomic nervous function of coke oven workers mainly by down-regulating the parasympathetic nervous function.<br>

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