Abnormalities in Cadmium Fluoride Kinetics in Serum, Bile, and Urine after Single Intravenous Administration of Toxic Doses to Rats

• Dote Tomotaro

  Department of Hygiene and Public Health, Osaka Medical College

• Adachi Kazuya

  Department of Hygiene and Public Health, Osaka Medical College

• Yamadori Emi

  Department of Hygiene and Public Health, Osaka Medical College

• Imanishi Masafumi

  Department of Hygiene and Public Health, Osaka Medical College

• Tsuji Hiroshi

  Department of Hygiene and Public Health, Osaka Medical College

• Tanida Eri

  Department of Hygiene and Public Health, Osaka Medical College

• Kono Koichi

  Department of Hygiene and Public Health, Osaka Medical College

抄録

Cadmium fluoride (CdF₂, CdF for short) is the most lethal and hepatotoxic of all Cd-containing compounds. The toxic effects of CdF appear to depend on its detoxification and elimination. This study was designed to determine the early dynamics of the absorption, systemic distribution, and metabolism of CdF. The kinetics of cadmium and fluoride were investigated in the blood, bile, and urine of rats as a model of accidental occupational exposure to CdF. The serum concentration-time profiles measured after intravenous CdF (1.34, 2.67 or 4.01 mg/ per kg body weight) administration were analyzed by compartmental modeling using the WinNonlin program. Bile and urine were collected for 300 min after the administration. The kinetic profiles indicate that the clearance of Cd was diminished in the 2.67 and 4.01 mg/kg groups, leading to a persistently high serum Cd level. The mean total biliary excretions of Cd in the 2.67 and 4.01 mg/kg groups were significantly higher than that in the 1.34 mg/kg group. The abnormal kinetics of Cd was attributable to severe hepatic injury that diminished the capacity for Cd accumulation. The elimination of serum F was delayed in the 4.01 mg/kg group. The mean urinary F excretion amount was not significantly higher in the 4.01 mg/kg group than in the 2.67 mg/kg group. The abnormal kinetics of F was attributable to nephrotoxicity that diminished its elimination from the kidney.<br>

収録刊行物

• ｊｏｕｒｎａｌ　ｏｆ　Ｏｃｃｕｐａｔｉｏｎａｌ　Ｈｅａｌｔｈ

  ｊｏｕｒｎａｌ　ｏｆ　Ｏｃｃｕｐａｔｉｏｎａｌ　Ｈｅａｌｔｈ 50 (4), 339-347, 2008

  公益社団法人 日本産業衛生学会

キーワード

• Cadmium fluoride
• Acute exposure
• Toxicokinetics
• Blood
• Bile
• Urine

詳細情報

• CRID: 1390001204456858496
• NII論文ID: 110006859189
• NII論文ID: 130004447432
• NII書誌ID: AA11090645
• DOI: 10.1539/joh.l8016
• ISSN: 13489585
• ISSN: 13419145
• NDL書誌ID: 9597313
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9597313
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1539%2Fjoh.L8016
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1539/joh.L8016
• Web Site: https://search.jamas.or.jp/link/ui/2009186355
• 本文言語コード: en
• データソース種別:
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  • NDL
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  • CiNii Articles
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