Effects of Grape Seed Proanthocyanidin Extracts on Peripheral Nerves in Streptozocin-Induced Diabetic Rats
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- CUI Xiao-pei
- Department of Geriatrics, Qi-Lu Hospital of Shandong University
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- LI Bao-ying
- Department of Geriatrics, Qi-Lu Hospital of Shandong University
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- GAO Hai-qing
- Department of Geriatrics, Qi-Lu Hospital of Shandong University
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- WEI Na
- Department of Geriatrics, Qi-Lu Hospital of Shandong University
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- WANG Wei-ling
- Department of Geriatrics, Qi-Lu Hospital of Shandong University
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- LU Mei
- Department of Geriatrics, Qi-Lu Hospital of Shandong University
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Diabetic peripheral neuropathy (DPN) is one of the most common diabetic chronic complications. The aim of this study was to clarify whether grape seed proanthocyanidins extracts (GSPE) are therapeutic agents against DPN. In this study, we used streptozocin (STZ) to induce diabetic rats. GSPEs (250 mg/kg body weight/d) were administrated to diabetic rats for 24 wk. Motor nerve conductive velocity (MNCV) and mechanical hyperalgesia were determined in the rats. Serum glucose, glycated hemoglobin, advanced glycation end products (AGEs), and tissue malondialdehyde (MDA) and superoxide dismutase (SOD) were determined. Light and electron microscopy were used to observe the changes of nerval ultrastructure.GSPE significantly increased the MNCV, mechanical hyperalgesia and SOD of diabetic rats (p<0.05) and reduced the AGEs and MDA of diabetic rats (p<0.05). After being treated by GSPE, the severe segmental demyelination was decreased and Schwann cells were improved. In conclusion, GSPE plays an important role against DPN. With the decreasing of AGEs and MDA, it can ameliorate oxidation-associated nerval damage. This study may provide a new recognition of natural medicine for the treatment of DPN.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 54 (4), 321-328, 2008
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詳細情報 詳細情報について
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- CRID
- 1390001206324243072
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- NII論文ID
- 110006873773
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD1cXhtV2ju7bF
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 9620040
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 使用不可