Parasitology: Effect of CD4[+] CD25[+] T cell-depletion on acute lethal infection of mice with Trypanosoma congolense
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- NAMANGALA Boniface
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine Faculty of Veterinary Medicine, The University of Zambia
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- YOKOYAMA Naoaki
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
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- IKEHARA Yuzuru
- National Institute of Advanced Industrial Science and Technology
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- TAGUCHI Osamu
- Aichi Cancer Center Research Institute
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- TSUJIMURA Kunio
- Hamamatsu University School of Medicine
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- SUGIMOTO Chihiro
- Research Center for Zoonosis Control, Hokkaido University
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- INOUE Noboru
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
書誌事項
- タイトル別名
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- Effect of CD4+CD25+ T Cell-Depletion on Acute Lethal Infection of Mice with Trypanosoma congolense
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Despite the immense socio-economic repercussions of African trypanosomosis (AT), there is currently no effective control measure against the disease. Characterization of mechanisms governing resistance and/or susceptibility to AT could suggest interventions that might lead to more effective disease control. The present study was designed in an attempt to address the possible role of CD4+CD25 + T cells during an acute lethal infection of mice with Trypanosoma congolense, the causative agent of AT in domestic animals, through selective depletion using anti-CD25 monoclonal antibody. Accordingly, CD4+CD25+ T-cell-depletion resulted in a significant reduction or delay in parasitemia, pathology, and mortality, as compared to controls. The apparent resistance in CD4+CD25 +-T-cell-depleted mice correlated with a profound suppression of Th2 cytokines in vitro and in vivo, culminating in a net Th1 cytokine environment. Cumulatively, these findings suggest that CD4+CD25+ T-cell- depletion improves the trypanotolerance of highly susceptible BALB/c mice acutely infected with the lethal T. congolense.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 70 (8), 751-759, 2008
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206429452416
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- NII論文ID
- 110006878921
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- HANDLE
- 10271/452
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- NDL書誌ID
- 9625173
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可