Clinical pathology: Total glutathione and glutathione reductase in bovine erythrocytes and liver biopsy

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  • ABD ELLAH Mahmoud Rushdi
    Veterinary Teaching Hospital, Faculty of Agriculture, Iwate University Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University
  • OKADA Keiji
    Veterinary Teaching Hospital, Faculty of Agriculture, Iwate University Department of Clinical Veterinary Science, The United Graduate School of Veterinary Medicine, Gifu University
  • GORYO Masanobu
    Department of Disease Control and Environmental Science, Faculty of Agriculture, Iwate University Department of Clinical Veterinary Science, The United Graduate School of Veterinary Medicine, Gifu University
  • KOBAYASHI Saori
    Department of Clinical Veterinary Science, The United Graduate School of Veterinary Medicine, Gifu University
  • OISHI Akihiro
    Veterinary Teaching Hospital, Faculty of Agriculture, Iwate University Department of Clinical Veterinary Science, The United Graduate School of Veterinary Medicine, Gifu University
  • YASUDA Jun
    Veterinary Teaching Hospital, Faculty of Agriculture, Iwate University Department of Clinical Veterinary Science, The United Graduate School of Veterinary Medicine, Gifu University

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タイトル別名
  • Total Glutathione and Glutathione Reductase in Bovine Erythrocytes and Liver Biopsy

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The goal of the present study was to measure the total glutathione level and glutathione reductase activity in bovine erythrocytes and liver biopsy. Five cows were injected intraperitoneally with DL-ethionine (12.5 mg/kg B.W.), and two control cows were injected with normal saline (0.9% NaCl). Ultrasonography guided liver biopsy, and blood samples were collected at 0, 4, 7 and 10 days after injection. The hepatic total glutathione level was significantly increased on Days 7 (p<0.05) and 10 (p<0.01), and hepatic glutathione reductase activity was significantly increased on Days 4 (p<0.05), 7 (p<0.01) and 10 (p<0.01). There were insignificant changes in the erythrocytic total glutathione level. The present study demonstrated that liver biopsy is a valuable tool for detecting oxidative stress and for diagnosing hepatic dysfunction in cattle from the viewpoint of the status of glutathione and glutathione reductase.<br>

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