Generation of Cyanide Ion by the Reaction of Hexamine and Losartan Potassium with Sodium Hypochlorite

• Adachi Atsuko

  Department of Hygienic Sciences, Kobe Pharmaceutical University

• Okano Toshio

  Department of Hygienic Sciences, Kobe Pharmaceutical University

抄録

The generation of cyanide ions by the reaction of pharmaceuticals containing nitrogen with sodium hypochlorite was examined using 20 different compounds. The generation of cyanide ions was observed in hexamine (hexamethylenetetramine), losartan potassium, metronidazole, and allopurinol. The largest generation was observed in hexamine. In both hexamine and losartan potassium, the amount of cyanide ion formed increased to a maximum at 45-60 min. The generation of cyanide ions was attributed to the formation of nitroso product by oxidizing action of sodium hypochlorite.

収録刊行物

• ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ

  ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ 54 (5), 581-583, 2008

  公益社団法人 日本薬学会

キーワード

• cyanide ion
• hexamine
• losartan potassium
• sodium hypochlorite

詳細情報

• CRID: 1390001204498617344
• NII論文ID: 110006935586
• NII書誌ID: AA11316464
• DOI: 10.1248/jhs.54.581
• ISSN: 13475207
• ISSN: 13449702
• NDL書誌ID: 9655086
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9655086
• Web Site: http://www.jstage.jst.go.jp/article/jhs/54/5/54_5_581/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009089178
• 本文言語コード: en
• データソース種別:
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