Laboratory animal science: Impairment of renal function and electrolyte balance in rabbit hemorrhagic disease

• CHEN Sheng-Yi

  Department of Veterinary Medicine, National Chung-Hsing University

• CHOU Chi-Chung

  Department of Veterinary Medicine, National Chung-Hsing University

• LIU Cheng-I

  Graduate Institute of Veterinary Pathology, National Chung-Hsing University

• SHIEN Jui-Hung

  Department of Veterinary Medicine, National Chung-Hsing University

書誌事項

タイトル別名

• Impairment of Renal Function and Electrolyte Balance in Rabbit Hemoorhagic Disease

抄録

Rabbit hemorrhagic disease virus (RHDV) induced viral fulminant hepatitis in adult rabbits. We investigated the damage of renal function and electrolyte balance in experimentally infected rabbit by measuring the related serum parameters to elucidate the pathogenesis of RHDV as an index for medical treatment. Nineteen New Zealand White rabbits, ten females and nine males, were each intramuscularly inoculated with 0.5 ml 50% rabbit lethal dose (RLD₅₀) rabbit hemorrhagic disease virus. Blood samples were collected at 0 hr post inoculation (HPI) and every 6 hr from 18 HPI repeatedly through 66 HPI. After virus inoculation, serum blood urea nitrogen (BUN), creatinine (CREA) and sodium (Na⁺) were elevated to a highly significant level (p<0.0001), whereas serum potassium (K⁺) was moderately elevated to a significant level (p<0.05). Hypoglycemia developed highly significantly (p<0.0001). Serum chloride ion (Cl^-) was the only parameter which did not change significantly (p=0.077). No significant sexual difference was observed among these parameters. Renal insufficiency progressed from 36 hr, as indicated by the increases in BUN and CREA; significant changes in electrolytes resulting in the increased osmolality of extracellular fluid that induced flow disturbance which consequently destroy the homeostasis in cells. Therefore, the later impairments in renal function and electrolyte balance might be an important threat for rabbits which might have survived from acute fulminant hepatitis in RHD.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 70 (9), 951-958, 2008

  公益社団法人 日本獣医学会

キーワード

• electrolyte balance
• rabbit hemorrhagic disease virus
• renal insufficiency
• serum

詳細情報

• CRID: 1390282681405431168
• NII論文ID: 110006946011
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.70.951
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 9654780
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9654780
• Web Site: http://www.jstage.jst.go.jp/article/jvms/70/9/70_9_951/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009003405
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可