Sequences and Polymorphisms of the Canine Monoamine Transporter Genes SLC6A2, SLC6A3, and SLC6A4 among Five Dog Breeds(Ethology) ARATA Sayaka OGATA Niwako SHIMOZURU Michito TAKEUCHI Yukari MORI Yuji 社団法人日本獣医学会 The journal of veterinary medical science 09167250 70 9 971 975 2008-09-25 Monoamine transporters have roles to regulate the monoamine concentrations in synaptic clefts in the central nervous system and are the targets of antidepressants and psychostimulants. They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily. We sequenced the full lengths of the coding regions of these genes for dogs and identified four single nucleotide polymorphisms (SNPs) in SLC6A2 and four in SLC6A3. One SLC6A3 SNP was non-synonymous and caused an amino acid substitution from threonine to serine. The genotype frequencies of these polymorphisms differed significantly among five breeds with different behavioral traits, suggesting that novel SLC6A2 and SLC6A3 SNPs would provide additional useful information for behavioral genetic studies in dogs. 2008-09-25 110006946014 AA10796138 9654857 ENG CJP NDL NII-ELS J-STAGE 3 29 Sequences and Polymorphisms of the Canine Monoamine Transporter Genes SLC6A2, SLC6A3, and SLC6A4 among Five Dog Breeds(Ethology) ARATA Sayaka OGATA Niwako SHIMOZURU Michito TAKEUCHI Yukari MORI Yuji Japanese Society of Veterinary Science The journal of veterinary medical science Monoamine transporters have roles to regulate the monoamine concentrations in synaptic clefts in the central nervous system and are the targets of antidepressants and psychostimulants. They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily. We sequenced the full lengths of the coding regions of these genes for dogs and identified four single nucleotide polymorphisms (SNPs) in SLC6A2 and four in SLC6A3. One SLC6A3 SNP was non-synonymous and caused an amino acid substitution from threonine to serine. The genotype frequencies of these polymorphisms differed significantly among five breeds with different behavioral traits, suggesting that novel SLC6A2 and SLC6A3 SNPs would provide additional useful information for behavioral genetic studies in dogs. ARATA Sayaka Laboratory of Veterinary Ethology,The University of Tokyo OGATA Niwako Laboratory of Veterinary Ethology,The University of Tokyo SHIMOZURU Michito Laboratory of Veterinary Ethology,The University of Tokyo TAKEUCHI Yukari Laboratory of Veterinary Ethology,The University of Tokyo MORI Yuji Laboratory of Veterinary Ethology,The University of Tokyo