イオンビームによって改質したコラーゲンの内皮化促進ステントへの応用と動物実験による考察  [in Japanese] In Vivo Animal Study of He^+ Ion Irradiated Collagen for the Development of Small Diameter Stent  [in Japanese]

In recent years, the stent technology available for endovascular treatment of aortic dissections has advanced tremendously. It is now possible to apply this minimally invasive technique to a wider range of pathology. The aim of this study was to develop anti-thrombogenic coronary stent using ion-beam technology. Our previous study indicted that He^+-irradiated collagen surface with a fluence of 1×10^<14> ions/cm^2 has excellent antithrombogenicity and cell attachment property. The ion beam irradiated collagen-coated Ni-Ti and available SUS stents demonstrated a high anti-thrombogenicity and endothelialization in animal studies. The implantation of ions into a collagen-coated surface is a promising approach for developing a new stent. It is therefore very likely that ion-implanted collagen-coated stents will be clinically applicable.